https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 20α-Hydroxysteroid Dehydrogenase Expression in the Human Myometrium at Term and Preterm Birth: Relationships to Fetal Sex and Maternal Body Mass Index https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49862 Wed 28 Feb 2024 15:09:16 AEDT ]]> Is peripartum maternal fever alone a reliable predictor of neonatal sepsis? A single-centre, retrospective cohort study https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49044 37 weeks) admitted to and treated in the neonatal unit at the Townsville University Hospital between March 2015 and March 2020. Neonatal sepsis was confirmed with positive neonatal blood culture. Data on neonatal birth/stay and maternal pregnancy were collected from the electronic medical records and neonatal database. Results: Data from 737 neonates who were admitted for treatment of EONS were analysed. Sixty % (426) reported maternal intrapartum fever, with 1.1% (5) of neonates developing blood culture-proven sepsis. Forty % did not report intrapartum fever (311), with 3% (9) of neonates developing sepsis. As such, the sensitivity and specificity of maternal fever are 1.14% and 97%, respectively. The positive predictive value was 35.7%, and the negative predictive value was 40.1%. Fourteen neonates developed EONS, and all of them were symptomatic. Seventy-eight % (334/426) of the women in the febrile group received epidural analgesia compared to 5% (16/311) in the afebrile group. Of the 95 neonates born to women with chorioamnionitis, one (1.0%) of the neonates born to women with chorioamnionitis developed sepsis. Conclusions: Intrapartum maternal fever is an unreliable predictor for EONS and leads to unnecessary antibiotic treatment. Symptoms in the neonate are a more reliable indicator of an ill neonate with blood culture-proven sepsis.]]> Wed 03 May 2023 13:55:00 AEST ]]> Preterm labor is a distinct process from term labor following computational analysis of human myometrium https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44767 Tue 30 May 2023 11:48:47 AEST ]]> Preterm labor with and without chorioamnionitis is associated with activation of myometrial inflammatory networks: a comprehensive transcriptomic analysis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51190 Thu 24 Aug 2023 14:39:18 AEST ]]>